USMLE Step 2 CK Lecture Notes 2019: Obstetrics/Gynecology (Kaplan Test Prep)

Figure II-4-12. Management  of  Endometrial Hyperplasia

Postmenopausal women taking estrogen replacement therapy must also be
treated with progestins to prevent unopposed estrogen stimulation, which may
lead to endometrial cancer. Reproductive age women with chronic anovulation
(e.g., PCO syndrome) should also be treated with progestins to avoid
endometrial hyperplasia from unopposed estrogen.