The most compelling theory of epithelial ovarian carcinogenesis suggests that
serous, endometrioid, and clear cell carcinomas are derived from the fallopian
tube and endometrium—not directly from the ovary.
Risk factors include BRCA1 gene, positive family history, high number of
lifetime ovulations, infertility, and use of perineal talc powder. Protective
factors include conditions that decrease the total number of lifetime ovulations.
Removal or occlusion of the fallopian tubes: bilateral salpingectomy or tubal
ligation
Decreased lifetime ovulations: combination steroid contraception, chronic
anovulation, breastfeeding, and short reproductive life