Autosomal recessive examples include the following:
Deafness Albinism Phenylketonuria
Congenital adrenal hyperplasia Sickle cell anemia Cystic fibrosis
Thalassemia Tay-Sachs disease Wilson diseaseX-linked recessive
These conditions are functionally dominant in men, but may be dominant or
recessive in women. There is no male-to-male transmission (because the father
gives only his Y chromosome to his son), but transmission is 100% male to
female. The usual transmission is from heterozygous females to male offspring
in an autosomally dominant pattern.
If one parent is homozygous and one is heterozygous, 50% of offspring will
be affected, and 50% will be carriers.
If both parents are homozygous, 100% of children will be affected.
Carrier states are common.