G
Activities (Gugul) — Alterative (f; DEP; KAB; KAP; MBB); Analgesic (1; JBU); Antiaging (f;
AKT); Antiaggregant (1; KAP; KEB; PNC; SKY); Antiarthritic (1; MPI); Antiatherosclerotic (1;
APA; KEB; MPI); Antiedemic (1; APA; KEB; MPI); Antiinflammatory (1; APA; KAP; KEB; PNC);
Antiobesity (1; KEB); Antioxidant (1; KEB); Antiseptic (f; DEP; KAP; WOI); Antispasmodic (1;
KAP; PNC); Antisuppurative (f; DEM; MPI); Antithrombic (1; KEB); Aperitif (f; DEP; KAB;
KAP); Aphrodisiac (f; DEP; KAB; KAP); Astringent (f; KAP; WOI); Bitter (f; KAB; MBB);
Cardioprotective (1; KEB); Carminative (f; DEP; KAB; KAP); Demulcent (f; DEP; KAB; KAP);
Diaphoretic (f; MPI; WOI); Digestive (f; WOI); Diuretic (f; WOI); Ecbolic (f; MPI); Emmenagogue
(f; KAP); Expectorant (f; DEP; KAB; WOI); Fibrinolytic (1; KEB); Hypocholesterolemic (1; PNC;
SKY); Hypoglycemic (1; MPI); Hypolipidemic (1; PNC); Hypotriglyceridemic (1; KEB; SKY);
Immunostimulant (1; WOI); Leucocytogenic (1; WOI); Lipolytic (1; AKT; APA; MBB; PNC; SKY);
Mucolytic (f; AKT); Phagocytotic (1; WOI); Thyrotropic (1; AKT; APA; PNC); Uterotonic (f;
WOI); Vermifuge (f; KAB).
Indications (Gugul) — Abscess (f; KAB); Acne (1; AKT; KEB); Adenopathy (f; AKT; KAB;
MBB); Amenorrhea (f; KAP); Anemia (f; DEP); Angina (1; AKT); Anorexia (f; DEP; KAB;
KAP); Arthrosis (1; AKT; APA; KAP; KEB; MBB; MPI); Ascites (f; KAB); Asthma (f; KAB);
Atherosclerosis (1; APA; KEB; MPI; SKY); Atony (f; WOI); Bite (f; KAB); Bronchosis (f;
BGB; WOI); Cancer (f; AKT; KAB; MBB); Cardiopathy (1; AKT; APA; KEB); Catarrh (f;
WOI); Cramp (1; KAP; PNC); Cyst (f; AKT; MBB); Dermatosis (f; DEP; KAB); Diabetes (1;
MPI); Dysmenorrhea (f; KAP); Dyspepsia (f; DEP; KAB); Dyspnea (1; AKT); Dysuria (f; DEP;
KAB); Edema (1; APA; MPI); Endometriosis (f; KAP); Enterosis (f; KAB); Fever (f; MPI;
WOI); Fracture (f; KAB); Fistula (f; KAB); Gas (f; DEP; KAB; KAP); Gastrosis (f; WOI);
Gingivosis (f; WOI); Gleet (f; DEP); Hay Fever (f; WOI); Hemorrhoid (f; DEP; KAB); Hepatosis
(f; MBB); High Blood Pressure (f; KAP); High Cholesterol (1; APA; KAP; PNC; SKY); High
Triglyceride (1; APA; KEB; SKY); Hyperlipemia (1; KAP; KEB); Hysteria (f; DEP); Immun-
odepression (1; WOI); Impotence (f; DEP); Inflammation (1; APA; KAB; KAP; KEB; MBB;
PNC); Ischemia (1; KEB); Laryngosis (f; WOI); Lassitude (f; KAP); Leprosy (f; DEP; KAP);
Leukoderma (f; KAB); Menorrhagia (f; KAP); Myosis (f; KAB); Neurosis (f; DEP; KAB;
KAP); Obesity (1; KEB; MBB; MPI; PNC); Odontosis (f; SKJ); Otosis (f; KAB); Pain (1; AKT;
JBU; KAP); Phthisis (f; WOI); Psoriasis (f; AKT); Pulmonosis (f; KAB); Pyorrhea (f; WOI);
Rheumatism (1; DEP; KAB; SKJ); Sciatica (f; DEP); Scrofula (f; KAB); Scurvy (f; DEP);
Rhinosis (f; WOI); Snakebite (f; KAB); Sore (1; DEP; KAB; SKJ); Sting (f; KAB); Stone (f;
KAB); Swelling (1; APA; KEB; MPI); Syphilis (f; DEP); Thrombosis (1; KEB); Water Retention
(f; WOI); Worm (f; KAB).
Dosages (Gugul) — 25 mg guggulsterones 2–3 ×/day (APA); 250–500 mg StX (5–10% guggul-
sterone) (APA; SKY); 1200–1500 mg guggulipid/day (ca 40–60 mg guggulsterone) (KEB);1.5
drachms (DEP).
Contraindications, Interactions, and Side Effects (Gugul) — Class 2b. Emmenagogue and
uterotonic (AHP). Anorexia, apprehension, colic, dermatosis, diarrhea, eructations, headache,
hiccup, nausea, and restlessness were documented side effects of crude oleoresin or guggulipid
therapy (CAN; KEB; SKY). Persons with diarrhea, hepatosis, and IBS should be cautious (SKY).
A practitioner should be consulted when treating high cholesterol or triglycerides (SKY). In view
of the lack of toxicological data, excessive use, especially during lactation and pregnancy, should
be avoided (CAN).
Extracts (Gugul) — Gugul resin lowers cholesterol and lipids in animals and humans. The
oleoresin fraction was antiarthritic and antinflammtory in rats (MED = 125 mg/kg rat). Aqueous
extracts are antiedemic (MPI). It inhibits platelet aggregation, causes inflammation in rats,
activates the thyroid in chickens and rats, and increases catecholamine biosynthesis and activity
in cholesterol-fed rabbits.