Medical Microbiology

80 2 BasicPrinciplesofImmunology

Table2. 6 TheMostImportantImmunologicalCytokinesandCostimulators

plusTheirReceptorsandFunctions

Cytokines/costimula-

tors/chemokines Receptor

Cytokines/cytokinereceptors

producedby Functions

Interleukins

IL-1 CD1 21 (a)b Macrophages

Endothelialcells

Hypothalamicfever,

NKcellactivation,

TandBstimulation

IL-2(T-cellgrowth

factor)

CD25(a)

CD1 22 (b),cc

Tcells T-cellproliferation

IL-3(multicolony

stimulatingfactor)

CD123,bc Tcells,Bcells,

thymicepithelial

cells

Synergisticeffectin

hematopoiesis

IL-4(BCGF-1,BSF-1)

(B-cellgrowthfactor,

B-cellstimulatingfactor)

CD1 2 4,cc Tcells,mastcells B-cellactivation,switch

toIgE

IL-5(BCGF-2) CD125,bc Tcells,mastcells Growthanddifferentia-

tionofeosinophilis

IL-6(interferon/IFNb 2 ,

BSF-2,BCDF)

CD126,

CDw 130

Tcells,

macrophages

Growthanddifferentia-

tionofTandBcells,

acute-phaseimmune

response

IL-7 CDw 127 ,cc Bonemarrow

stroma

Growthofpre-Band

pre-Tcells

IL-1 0 Tcells Macrophages,reduction

ofTH1cytokines

IL-9 IL-9R,cc Tcells Effectonmastcells

IL-1 0 Thelpercells

(especiallymouse

TH2),macro-

phages,

Epstein-Barrvirus

Efficientinhibitorfor

macrophagefunctions,

inhibitsinflammatory

reactions

IL-1 1 IL-11R,

CDw 130

Stromal

fibroblasts

Synergisticeffectwith

IL-3andIL-4inhemato-

poiesis

2

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Kayser, Medical Microbiology © 2005 Thieme

All rights reserved. Usage subject to terms and conditions of license.