Medical Microbiology

(ff) #1
82 2 BasicPrinciplesofImmunology

Table2. 6 Continued:TheMostImportantImmunologicalCytokines...

Cytokines/costimula-
tors/chemokines Receptor

Cytokines/cytokinereceptors
producedby Functions

TNF(tumornecrosisfactor)family
TNFa(cachexin) p55,p75,
CD120a,
CD120b

Macrophages,
naturalkillercells

Localinflammations,
endothelialactivation

TNFb(lymphotoxin,
LT,LTa)

p55,p75,
CD120a,
CD120b

Tcells,Bcells Endothelialactivation,
organizationofsecond-
arylymphoidtissues
LTb Tcells,Bcells Organizationofsecond-
arylymphoidtissues
CD40ligand(CD40-L) CD40 Tcells,mastcells B-cellactivation,class
switching
Fasligand CD95(Fas) Tcells Apoptosis,Ca2+-inde-
pendentcytotoxicity

Chemokines
IL-8(prototype)
CXCL8

CXCR1,
CXCR2

Activatedendo-
thelium,activated
fibroblasts

Attractionofneutro-
phils,degranulationof
neutrophils
MCP-1(monocyte
chemoattractant
protein)
CCL2

CCR2 Activatedendo-
thelium,tissue
macrophages,
synovialcells

Inflammation

MIP-1a(macrophage
inflammatoryprotein)
CCL3

CCR5,CCR1 Tcells,activated
Mf

Proinflammatory
HIVareceptor

MIP-1b
CCL4

CCR5 Tcells,activated
Mf

Proinflammatory
HIVareceptor
RANTES(regulatedon
activation,normal
Tcellexpressedand
secreted)
CCL5

CCR5,CCR1,
CCR3

Tcells,blood
platelets

Inhibitscellularentry
byM-trophicHIV,
proinflammatory

IP-1 0 (interferon
gamma-inducible
protein)
CXCL1 0

CXCR3 Inflamedtissue
duetoeffectsof
IFNc

Proinflammatory

2


All rights reserved. Usage subject to terms and conditions of license

Kayser, Medical Microbiology © 2005 Thieme
All rights reserved. Usage subject to terms and conditions of license.
Free download pdf