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................................................................................................................2 R. M. Zinkernagel
...........................................................................................................................................................................................................................................................................................................................................................................................................XIV Contents
Kayser, Medical Microbiology © 2005 ThiemeGeneral Epidemiology 25
Epidemiological Terminology 26
Transmission, Sources of Infection 26
Transmission 26
Sources of Infection 30
The Fight against Infectious Diseases 31..........................................
....................................Legislation 31Diversity within the Variable Domains of the
Immunoglobulins 53T-Cell Specificity and the Major Histocompatibility
Complex (MHC) 58Exposure Prophylaxis 31
Immunization Prophylaxis 31
Principles of Sterilization and Disinfection 34
Terms and General Introduction 34
Terms 34
The Kinetics of Pathogen Killing 35
Mechanisms of Action 36
Physical Methods of Sterilization and Disinfection 37
Heat 37
Radiation 38
Filtration 38
Chemical Methods of Sterilization and Disinfection 39
Practical Disinfection 40Basic Principles of Immunology 43Introduction 43
The Immunological Apparatus 45Immunoglobulin Structure 50The B-Cell System 48The Different Classes of Immunoglobulins 54
The T-Cell System 57
T-Cell Receptors (TCR) and Accessory Molecules 57T-Cell Maturation: Positive and Negative Selection 63
T-Cell Subpopulations 64
Immune Responses and Effector Mechanisms 66
B Cells 67..............................
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