Medical Microbiology

Somaticmutation/recombination:Rear-

rangementsofgenesinsomaticcells

(asopposedtogermlinecells),result-

ing inanewlycombinedDNAse-

quencewhichisnotheritable.

Splenomegaly:Splenicenlargement;of-

tenobservedincasesofhematopoie-

ticcelltumors,vascularcirculatory

problems,orfollowingvariousparasi-

ticinfections.Canalsobeusedasa

measureofGVHreactions.

SRBC: Sheepredblood cells(erythro-

cytes).

Stripping:Theprocessbywhichantibo-

dies remove antigen determinants

fromtargetcells.

Suppressorcell:Aproposedantigen-spe-

cificT-cellsubpopulationwhichactsto

reducetheimmuneresponsesofother

TcellsorBcells.Thissuppressioncan

alsobeofanonspecificnature.

Syngeneic: Animals produced by re-

peated inbreeding,ormonozygotic

twins,whichareconsideredsyngeneic

wheneachpairofautosomeswithin

theindividualsisidentical.

TATA: Tumor-associated transplantation

antigens.

Tc:CytotoxicTcell(CD8+Tcell)orCTL.

TCGF:T-cellgrowthfactor;identicalwith

interleukin 2 (IL-2).

T-dep/T-ind:Tcell-dependent/Tcell-inde-

pendent;anantibodyresponsetoT-

dependentantigensisonlypossible

if(MHC-restricted)T-cellhelpisalso

available.

T-DTH:ATcellthatcontributestodelayed

typehypersensitivityreactions.

TECK:Thymus-expressedchemokine.

Tetramer:BiotinylatedMHCclassI,or

classII,moleculecomplexedtopep-

tideand boundto labeledavidin.

Usedtodeterminethepresenceof

peptide-specificTcells.

TGF:Transforminggrowthfactor.

TH:Thelpercells(CD4+Tcell;seealso

Helpercells).

Thy:AcellsurfaceantigenofmouseT

cells;thereareseveralallelicvariants

ofthismarker.

TNF:Tumornecrosisfactor.

Tolerance:Astateofspecificimmunologi-

calunresponsiveness.

Transformation(blastic):Morphological

changesinalymphocyteassociated

withtheonsetofcelldivision.

Transplantationantigens:SeeMHC.

Wiskott-Aldrichsyndrome:Asex-linked,

inheritable,recessive,combinedim-

munedeficiencyinwhichIgManti-

bodyproductionandcellularimmune

reactionsareimpaired.

144 2 BasicPrinciplesofImmunology

2

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Kayser, Medical Microbiology © 2005 Thieme

All rights reserved. Usage subject to terms and conditions of license.