Medical Microbiology

386 7 GeneralVirology

ReplicationoftheViralGenome

+

+ + + + +

+

Polymerase Polymerase

a

+

–

Polymerase Polymerase

+ +

b –

c

+– Polymerase

Polymerase +– +–

+ + +

d

Reverse transcriptase

Integration in cell genome

Cellular transcriptase

RNA DNA

+

+ – +

+ +

+ + + + + DNA DNA

Cell–Virus–Cell RNA

e

RNA DNA

Cellular transcription Maturation

RNA

Reverse transcriptase

DNA RNA DNA

DNA

DNA partially

+

+ + – – +

7