450 8 VirusesasHumanPathogen
StructureandGenomicOrganizationofHIV
LTR
vpr
gag vif
p55
env
nef
gp 1 60
pol
rev
tat
Structural proteins
Genomic organization
Envelope
Capsid
p18 p24 p1 5
RNA
p66/51/1 0 p3 1
LTR
vpu
gp 1 20 gp 4 1
Fig.8. 14
Gene Geneproduct Function
Structuralgenes:
gag p55 p55 Nucleocapsid,precursorofp18,p24,p1 5
p1 8 Matrixprotein
p2 4 Capsidprotein
pol Polymeraseregion
p66/51/1 0 Reversetranscriptase/RNase/protease
p3 1 Integrase
env gp1 60 Glycoprotein,precursorofgp120,gp4 1
gp1 20 Surfaceprotein(bindstoCD4moleculeofhost
cell)
gp4 1 Transmembraneprotein
Regulatorygenes,seetext.
8
Kayser, Medical Microbiology © 2005 Thieme