Medical Microbiology

452 8 VirusesasHumanPathogen

Table8. 4 DiagnosticDefinitionsforAIDSinAdults

CD4+Tcells/ll Clinicalcategories

A B C

>500 A1 B1 C1

200 – 499 A2 B2 C2

<200 A3 B3 C3

A3,B3,andC1– 3 confirmAIDSdiagnosis

Clinicalcategories

A:Asymptomaticoracute(primary)HIVinfection;persistentgeneralizedlymphade-

nopathy(LAS)

B:Symptomsindicativeofweakenedcellularimmunedefenses,butnoAIDS-defining

diseases.

C:AIDS-definingdiseases:

Viruses

HSV:chroniculcer,esophagitis,bronchitis,pneumonia

VZV:generalizedzoster

CMV:retinitis,encephalitis,pneumonia,colitis

JCvirus:progressivemultifocalleukoencephalopathy

HIV:encephalitis

HIV:wastingsyndrome

Bacteria

Recurrentsalmonellarsepticemia

Recurrentpneumonia

Mycobacterialtuberculosis,pulmonaryandextrapulmonaryforms

Opportunisticmycobacteria(M.avium,etc.),disseminatedorextrapulmonary

Protozoans

Cryptosporidium:chronicdiarrhea

Isosporabelli:chronicdiarrhea

Toxoplasmagondii:encephalitis

Fungi

Candida:esophagitis,pneumonia,bronchitis

Histoplasma,Cryptococcusneoformans,coccidiosis:extrapulmonary,disseminated

Pneumocystiscarinii:pneumonia

Malignomas

Kaposisarcoma

Invasivecervicalcarcinoma

B-celllymphomaEBV-positive

8

Kayser, Medical Microbiology © 2005 Thieme