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Grey's Anatomy is an American medical drama television series that premiered on

March 27, 2005, on the American Broadcasting Company (ABC) as a mid-season

replacement. The fictional series focuses on the lives of surgical interns, residents,

and attendings as they develop into seasoned doctors while balancing personal and

professional relationships. The title is an allusion to Gray's Anatomy, a classic human

anatomy textbook first published in 1858 in London and written by Henry Gray.

Shonda Rhimes developed the pilot and continued to write for the series until 2017.

Krista Vernoff, who previously worked with Rhimes, is now the showrunner. Rhimes

was also one of the executive producers alongside Betsy Beers, Mark Gordon, Krista

Vernoff, Rob Corn, Mark Wilding, and Allan Heinberg, and recently, Ellen Pompeo.

Although the series is set in Seattle, it is filmed primarily in Los Angeles, California.

The series revolves around the title character, Dr. Meredith Grey, played by Ellen

Pompeo. Grey is first featured as an intern and later becomes the chief of general

surgery, all the while exploring the ups and downs of a surgeon's life. The original

cast consisted of nine star-billed actors: Pompeo, Sandra Oh, Katherine Heigl, Justin

Chambers, T. R. Knight, Chandra Wilson, James Pickens Jr., Isaiah Washington, and

Patrick Dempsey. The cast has undergone major changes throughout the series' run.

At the start of the seventeenth season, the show had a large ensemble of fifteen

actors—including three characters from the original cast (Meredith Grey, Miranda

Bailey and Richard Webber).

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