How to Change Your Mind

A key question that the science of psychedelics has not even begun to
answer is whether the new neural connections that psychedelics make
possible endure in any way, or if the brain’s wiring returns to the status
quo ante once the drug wears off. The finding by Roland Griffiths’s lab
that the psychedelic experience leads to long-term changes in the
personality trait of openness raises the possibility that some kind of
learning takes place while the brain is rewired and that it might in some
way persist. Learning entails the establishment of new neural circuits;