Cell Biology: Intracellular Trafficking 13159.The two major secretory pathways A → B→ C→ D (pathway I) and
C→ E (pathway II) are illustrated in the diagram. Albumin secretion by
hepatocytes occurs by pathway II. In a patient with cirrhosis, the serum
levels of albumin are reduced. The reduced secretion of albumin most
likely occurs through:
(Modified, with permission, from Avery JK:Oral Development and Histology,3/e. New York:
Thieme Medical, 2001.)
a. Reduced binding of “A” to receptors
b. Reduced numbers of functional hepatocytes
c. Down-regulation of “B” on hepatocytes
d. Reduced activity of the cAMP-activated signal transduction system
e. Increased cyclic AMP levels