0071509674.pdf

Cell Biology: Nucleus

Questions

DIRECTIONS: Each item below contains a question or incomplete

statement followed by suggested responses. Select the one bestresponse to

each question.

61.A newborn boy is born with first arch congenital malformations clas-

sified as Treacher-Collins syndrome, which is an autosomal dominant

inherited disorder. The Treacher Collins-Franceschetti syndrome 1 (TCOF)

gene encodes the protein treacle. Treacle is localized to the structure

labeled with the arrows in the accompanying transmission electron micro-

graph. Treacle is most likely involved in which of the following?

139

a. Assembly of ribosomal subunits into mature ribosomes

b. Translation of cytosolic proteins

c. Transcription of nuclear proteins

d. Transcription of ribosomal proteins

e. Organelle degradation

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