100.A 46-year-old woman who has been a type I diabetic for 35 years vis-
its your family medicine office. She has foot ulcers on both her right and
her left feet. You prescribe Beclaperin gel, a prescription drug for the treat-
ment of diabetic foot ulcers. It contains platelet-derived growth factor
(PDGF). Which of the following is the most likely mechanism for the
action of PDGF in the improvement of wound healing?
a. Acceleration of chemotaxis of monocytes-macrophages
b. Inhibition of vascular smooth-muscle cell proliferation
c. Inhibition of fibroblast proliferation
d. Inhibition of granulation tissue formation
e. Secretion of type II collagen from fibroblasts
Connective Tissue 177