149.A 35-year-old woman presents with weakness and spasticity in the
left lower extremity, visual impairment and throbbing in her left eye, diffi-
culties with balance, fatigue, and malaise. There is an increase in cere-
brospinal fluid (CSF) protein, elevated gamma globulin, and moderate
pleocytosis. MRI confirms areas of demyelination in the anterior corpus
callosum. Imaging identifies plaques which are hyperintense on T 2 -
weighted and FLAIR images and hypointense on T 1 -weighted scans. Which
of the following cells are specifically targeted in her condition?
a. Microglia
b. Oligodendrocytes
c. Astrocytes
d. Schwann cells
e. Axons of multipolar neurons
238 Anatomy, Histology, and Cell Biology