2.A married couple, with diagnosed 6-year-long infertility, presents to the
fertility clinic. A spermocytogram, confirmed by electron microscopy, reveals
that the husband produces all spermatozoa with rounded heads, a condition
known as globozoospermia. The missing sperm structure is associated with
which of the following?
a. Loss of decapacitation factors
b. Retention of the developing spermatids from Sertoli cells
c. Maturation of lytic enzymes
d. Mitotic activity
e. Meiotic divisions
3.A 38-year-old (gravida 0, para 0) woman is recently married and preg-
nant. The zygote is a result of a haploid ovum fertilized by her husband’s
sperm. Which of the following is required for continuation of the second
meiotic division to produce the haploid ovum?
a. Elevation of progesterone titers
b. Expulsion from the mature follicle
c. The environment of the oviduct and uterus
d. Fertilization by a spermatozoon
e. The presence of human chorionic gonadotropin (hCG)
4.A married couple, diagnosed with infertility present to the fertility
clinic. The husband’s semen contains only 40 million sperm total with a
forward motility index slightly below normal. A hamster egg penetration
assay was performed in which hamster eggs are collected and their zona
pellucidae are enzymatically removed prior to mixing with sperm. The
husband’s sperm have normal morphology, but his penetration assay
results are 3.7% (normal, 10%). The hamster egg penetration assay
requires which of the following?
a. Sperm formation, maturation and penetration
b. Addition of cholesterol to the sperm plasma membrane
c. A decrease in the fluidity of the sperm plasma membrane
d. Sequestration of acrosomal enzymes
e. Capacitation, acrosome reaction and penetration
72 Anatomy, Histology, and Cell Biology