undergo separate reactions with compounds B 1 ,B 2 and B 3 respectively (Figure
6.2). At the same time compounds A 2 and A 3 would also be undergoing
A 1A 1 −B 1 −C 1A 1 −B 2A 1 −B 3A 2 −B 1A 2 −B 1 −C 3A 2 −B 3A 2 −B 1 −C 1A 2 −B 2 −C 1RCOCl RCONHCHCOOR"A 1 −B 1 −C 2R'R"'NH 2A 2 −B 3 −C 2H R'
2 NCHCOOR"
RCONHCHCONHR"'R'A 2 −B 1 −C 2A 1 −B 3 −C 1A 1 −B 1 −C 3A 1 −B 2 −C 3A 1 −B 2 −C 2A 1 −B 3 −C 2A 1 −B 3 −C 3A 1 −B 1A 1 −B 2 −C 1A 2 −B 3 −C 1A 2 −B 2 −C 3A 2 −B 3 −C 3A 3 −B 1 −C 2A 2 −B 2 A 2 −B 2 −C 2A 3 −B 1A 3A 3 −B 3A 3 −B 1 −C 1A 3 −B 1 −C 3A 3 −B 3 −C 2A 3 −B 2 −C 1A 3 −B 3 −C 1A 3 −B 2 −C 3A 3 −B 3 −C 3A 3 −B 2 A 3 −B 2 −C 2A 2Stage 1 Stage 2Figure 6.2 The principle of combinatorial chemistry illustrated by a scheme for synthesis of a
library of 27 polyamides using three building blocks at each stage
114 COMBINATORIAL CHEMISTRY