Fundamentals of Medicinal Chemistry

(continued)

(7) parameter(s) and indicate the best analogue for further investigation if a drug

with a reasonable duration of action is required. Assume that the absorption

and elimination of the drug follows first order kinetics.

(7) A patient is being treated with morphine by intravenous infusion. The steady

state plasma concentration of the drug is to be maintained at 0.04gcm

 3

.

Calculate the rate of infusion necessary assuming a first order elimination

process (for morphineVdis 4.0 dm

3

andt1/2is 2.5 hours).

180 PHARMACOKINETICS