Fundamentals of Medicinal Chemistry

(continued)

(5) Explain the meaning of the term ‘synthon’. Draw the best synthons and their

corresponding real compounds for each of the following compounds:

(i)

O

O

CH 3

Ph

O

OC COOC 2 H 5

Cl COOC^2 H^5

OH

O

CO

CO

(ii) (iii) (iv)

(6) What is the significance of the initials FGI in the disconnection approach to

designing synthetic pathways? Suggest the best disconnection sequences for

the synthesis of each of the following compounds:

(i)

OH

NHCOCH 3

COOH

(ii)

QUESTIONS 221