entered the brain, it is easily oxidized to the quaternary salt, which because of its
charge cannot return across the blood–brain barrier.Chapter 10
(1) (i), (ii) See Section 10.2. (iii) See section 10.1.
(2) See Section 10.2.
(3) See Section 10.2.3.
(4) See Figure 10.10. Use propyliodide instead of ethyliodide in Figure 10.10.
(5) Synthon, see Section 10.3.1.
(i)
(ii)
(iii)
OOCH 3 CH 3 CH 3Ph Ph −O Ph−O−O+ O +HOHOO
OC OCOH
HOOC++COOC 2 H 5COOC 2 H (^5) COOC
2 H 5 COOC 2 H 5
Cl Cl COOC 2 H (^5) Cl COOC 2 H 5
OH OH
C
O
H H
2 C
(iv) A pericyclic disconnection. O +
CO
CO
O
CO
CO
(6) FGI, see section 10.3.1.
(i)
HO
HO HO HO
NH COCH 3 HO
HO
NH
−
NH 2
NH 2
CH 3 COCl
or
(CH 3 CO) 2 O
Reduction Nitration
+COCH
3
FGI
NO 2 + NO 2
270 ANSWERS TO QUESTIONS