Fundamentals of Medicinal Chemistry

Bacteria (Continued)

bacteriophages, 242

cell envelope, membrane and walls, (see

cells)

Gram positive, 136, 241, 242, 243

Gram negative, 136, 138, 241, 243, 244

lysis, 241

periplasmic space, 241

Bacitracin A, 137

Ball and stick model, 99

Benzocaine, 216

Benzoic acid, 191

Benzylpenicillin, 74, 137

Bioavailability, (SeePharmacokinetics)

Bleomycins, 155

Blood-brain barrier, 79, 198–199, 265

Bumetamide

Bupivacaine, 168

Busulphan, 153

Butane, 106

Caffeine, 168

Camphor, 24

Camptothecin, 150

Cancer, 249, 261

S,S-Captopril, 209

Carbamazepine, 187

Carbohydrates, 10

monosaccharides (seeMonosaccharides), 10

oligosaccharides (seeMonosaccharides), 10

polysaccharides (seemonosaccharides), 10

Carboplatin, 153

Carmustine, 153

a-Carotene, 24

Cartesian coordinates, 96

Ceftazidime

Cell

envelope, 131, 242, 245–246

membrane, 245–246

wall, 19, 241, 242

Cellulose, 17

Cephalothin, 137

a-Cephalins, 25

Cephalosporins, 136

Ceramide, 25

Cerebrosides, 25

Chemotherapeutic index, 40

Chloramphenicol, 68

Chloramphenicol sodium succinate, 68

Chloramphenicol, 74, 188, 191

Chloroquine, 54, 151

Chloroxylenol, 133

Cholesterol, 22, 134

Chondroitins, 19

Ciclopirox, 133

Cimetidine, 40, 41

N 4 -Cinnamyllidenesulphanilamide, 69

Citric acid, 65

Citrulline, 3

Clavulanic acid, 138

Clearance, 166–169

extraction, 168,

extraction ratio, 168, 169

Clioquinol, 133

Clomipramine, 74

Clonidine, 76

Clotrimazole, 133

Cmax, 176

Cocaine, 38, 169

Codeine, 169

Codon, 33

Collagen,9

Combinatorial chemistry, 42, 113–130, 138

computerised tagging, 126 –127

deconvolution, 122, 128–130

encoding methods, 122, 123–127

Edman sequencing method, 124

Furka split and mix, 117, 121–122, 123

general techniques, 116–117

general design of syntheses, 115–116

handles, 117

high throughput screening, 113

Houghton, 117

libraries, 113, 119, 120, 121, 127

linker, 117, 118, 123

Merrifields peptide synthesis, 117

oligonucleides as tags, 124

parallel synthesis, 118–121, 127

pin and well array, 119, 121

sequential synthesis, 113, 115

sequential tagging methods, 123–124

solid support method, 117–127

solution methods of synthesis, 127–128

tea bag method, 117

template, 115

Still’s binary code system, 124 –126

well grid array, 118, 119

Zuckermann encoding method, 125

Computational chemistry, (seeMolecular

modelling)

276 INDEX