Configurations
amino acids, 4
monosaccharides, 13Conformation, 6
Corticoids, 204
Cortisol, 74
Craig plots, 88
D-Cycloserine, 137
Cytarabine, 148
Cytochrome c, 10
Cysteine, 6, 142
Cytochrome P-450, 134, 186
Cyclophosphamide, 195
Cytoplasmic membrane, 131
Cytosine, 27
Dacarbazine, 153
Dapsone, 68
Desmethylimipramine, 188
Deoxyadenosine triphosphate (dATP),
28Deoxycytidine, 27
Deoxy-haemoglobin, 6
Deoxyribonucleic acids (DNA), 26
B-DNA, 28, 29
complementary base pairs 28
daughter strand, 29
DNA ligase, 30, 155
DNA polymerases, 29
hydrogen bonding in, 29
lagging strand, 30
leading strand, 30
Okazaki fragments, 30
replication, 28, 29,
stop and start signals, 32
structure, 28Deoxyribose, 15
Diazepam, 169, 185
Dibenazepine drugs, 77
Diethyanolamine, 65
Diethylstilbestrol, 54, 199
Digitalis, 44
Dihydrofolic acid, 148
Dihydrofolate reductase, 99, 148, 149
Dihydropteroate synthetase, 150
Dimercaprol, 192
Diosgenin, 203, 204
Dipenicillin, 74
Diphenhydramine, 76
Disconnection, (seedrug synthesis)
Disopyramide, 168
1,2-Distearoylglycerol, 21
3-(3,4-Dimethoxyphenyl)-butyrolactam, 74
Dopamine, 61, 190
Dose, 167, 231
Doxylamine, 68
Drugs, 37
activity, 37, 79
administration (seedrug administration)
analogues, 39, 71, 89, 145, 166, 193, 194,
233
bioavailability, (see Pharmacokinetics)
buccal absorption, 79
classification, 45
chemotherapeutic index, 40
discovery and design, a historical outline, 39
dissolution, 62, 172
distribution, 47
lead compound, 39, 45, 57, 62, 63, 65, 66, 71,
89, 145, 166, 168, 193, 194
lipophilicity, 78, 79–81, 134, 197
‘me-too drugs’, 45
pharmacodynamic phase (seedrug action)
pharmacokinetic properties (seedrug action)
pharmacophore, 41, 67, 71, 145
quantitative structure-activity relationship
(Seequantitative structural-activity
relationships)
side effects, 38
sources, 43
stability, 50
structure-activity relationship (SAR), (see
Structural-activity relationships)
tachyphylaxis, 38
therapeutic index, 40
transfer through membranes, 62
Drug action, 49, 131–157
absorption, 47, 49, 75, 79, 159, 161, 172, 173,
174, 175, 176, 177
administration, 47, 159, 160
allylamines, 134
alkylating agents, 147, 152–153
antibacterial agents, 135–138
antibiotics (Seeantibacterial agents)
antifungal agents, 132–133
antisense drugs, 152
antiviral drugs, 155–157, 263
azoles 133–134
biological half life (t1/2), 165, 166, 177
cell wall inhibition, 136–138INDEX 277