Fundamentals of Medicinal Chemistry

classification, 256

effectors, 257

feedback regulators, 257

isoenzymes, 267

isofunctional enzymes, 255

metal ion clusters, 255

metalloenzymes, 255

modulators, 257

nomenclature, 256

proenzymes, 255, 257

regulators, 257

structure and species, 267

zymogens, 255

Enzyme inhibitors, 147, 150–151

active site directed, 140–141

competitive inhibitors, 139

irreversible, 138, 139, 140–142

mixed non-competitive inhibitors, 138

non-competitive inhibitors, 139

reversible, 138–140

suicide inhibitors, 140, 141–142

transition state inhibitors, 142–144

uncompetitive inhibitors, 138, 140

Epimers, 14

Ergosterol, 22, 134

Erythrose, 11, 15

Essential oils, 23

Ethacrynic acid, 192

Ethambutol, 168

Ethanoic acid, 65

Ether phospholipids, 24
Ethnopharmacology, 43

1-Ethoxycarbonyl-2-

trimethylaminocyclopropane, 59

Ethylb-D-deoxyriboside, 16

Ethofylline, 69

Eucalyptol, 24

Eukaryotes, 131, 132, 157, 245

Excipients, (seedrug administration)

Exogenous species, 57, 149

Extracellular fluid, 131, 245

Fatty acids, 20

Ferritin, 4

Fibrinogen, 4, 10

First order kinetics, 163, 165, 167, 171, 175, 176

First pass metabolism, (seePharmacokinetics)

Fluconazole, 133

Fluorouracil, 148, 149, 150

Fosfestrol, 199

Fosomycin, 137

Functional group interconversions, 216, 217,

220

Fructose, 11, 14, 15

Furanose, 11, 15

Fusidic acid, 46

Fungicidal action, 133

Fungistatic action, 133

Gangliosides, 25, 26

Genes, 30

exons, 31, 32

genome, 31, 32

genetic code, 33

gene transcription, 248

human genome project, 31

introns, 31

g-Globulin, 10

D-gluco-Heptulose, 15

Guanine, 27

Guanosine, 27

N 4 -(b-D-Glucopyranosyl)

sulphanilamide, 16

Glucosamine, 10, 11

Glucosazone, 14

Glucose, 4, 11, 12, 14, 15, 19

a-Glucosidase, 18

b-D-Glucuronic acid, 18

Glutamic acid, 2

Glutamine, 2, 8

Glutathione, 7

Glutathione S-transferase, 192

Glycans, 17

Glycerides (seeAcylglycerols)

Glycerol, 21

Glycine, 2, 124, 149

Glycogen, 19

Glycolipids, 18, 25

subclassification, 25, 26

Glycone, 15

Glycoproteins, 6, 16, 18, 19, 157

Glycosaminoglycans, 19

Glycosides, 15

examples of, 16

glycosidic link, 15, 16, 17, 19, 26

nomenclature, 16

G-protein, 248

Gramicidin A, 135, 136

Griseofulvin, 132

INDEX 279