Fundamentals of Medicinal Chemistry

Ribonucleic acids (RNA), 26

anticodon, 34

classification, 33

codon, 33

hair pin loops, 31

heterogeneous nuclear RNA (hnRNA), 33

hydrogen bonding in, 30, 32

messenger RNA (mRNA), 33

premessenger RNA (pre-mRNA), 33

primary transcript RNA (ptRNA), 33

ribosomal RNA (rRNA), 34

transfer RNA (tRNA), 32, 33, 34

transcription, 31, 32, 150,151

Ribose, 11, 15

Ribosomes, 31, 33, 34

Ricinoleic acid, 20

Rimantadine hydrochloride, 156

RNA polymerases, 32

Rolipram, 74

Salicylic acid, 200

Salt bridge, 10

Secondary messengers, 247

Selegiline, 59

Serine, 2, 142

Serum albumin, 10

Sickle-cell anaemia, 8, 239

Silk fibroin, 9

Soft drugs, 194
Solubility and drug design, 61

dissolution, 62, 172

hydrogen bonding, 62, 63

partition coeficient, 172

salt formation, 64

structure, 63

water solubility, 62, 63, 65

Sphingomyelins, 24, 25

Spironolactone, 46

Squalene, 134

S-S bridges, 6, 7

Starch, 19

Stearic acid, 20

Stereochemistry in drug design

configuration, 60

conformation, 60

structurally rigid groups, 59

Stereoelectronic structure, 41, 53

Stereoisomerism

biological significance, 52, 54, 60,

Steroids, 21

conformations, 22

structural formula, 22

Streptomycin, 43

Structure-activity relationship (SAR),

40, 42, 71–77, 116, 134, 145, 148, 152

Succinate dehydrogenase, 139

Succinylsulphathioazole, 69

Sugars (seeCarbohydrates)

Suicide inhibitors, 140, 141–142

Sulbactam, 138

Sulconazole, 133

Sulphatides, 26

Sulphamethoxazole, 62, 63

Sulphanilamide, 191, 195

Sulphathioazole, 69

Sulphonamides, 62, 63, 151

Synthons, 214

Tachyphylaxis, 8

Taqpolymerase procedure, 124

Tartaric acid, 65

Tautomerism, 4

Taxol, 44

Teichoic acids, 242, 243

Temazepam, 185

Temozolomide, 153

Terbinfine, 133

Terbutaline, 144

Terconazole, 133

Terpenes, 22

classification, 23

isoprene rule, 23

Testosterone, 22, 46

Tetracaine, 113

Tetracycline, 43

Thalidomides, 54, 236

Theophylline, 69

Therapeutic index, 40

Therapeutic window, 48, 170, 174, 176

Thioguanidine, 148, 149

Thrombin, 4

Thromboxane, 228, 229

Thymidylate synthetase

Thymine, 27

Tilorone, 157

tmax, 176

Tocainide, 194, 195

Tollens reagent, 14

Tolmetin-glycine, 197, 198

Tolmetin sodium, 198

284 INDEX