ISS short- and long-term cultured cells grew faster than the ground control cells. And, in both
cases, no differences were observed between microgravity and 1G.
ISS cultured cells generated more intracellular reactive oxygen species (ROS) and increased the
expression of heat shock proteins (HSPs) and antioxidant enzymes compared with the control
cells. The results suggest that oxidative stress occurs in cells in low-Earth orbit.
PUBLICATION(S)
Indo HP, Nakanishi I, Ohkubo K, et al. Comparison of in vivo and in vitro antioxidative
parameters for eleven food factors. RSC Advances. 2013;3(14):4535. doi: 10.1039/c3ra22686g.
Indo HP, Inanami O, Koumura T, et al. Roles of mitochondria-generated reactive oxygen species
on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line, HLE. Free Radical
Research. August 2012;46(8):1029-1043. doi: 10.3109/10715762.2012.698012.
Majima HJ, Indo HP, Suenaga S, Matsui H, Yen H, Ozawa T. Mitochondria as possible
pharmaceutical targets for the effects of vitamin E and its homologues in oxidative stress-
related diseases. Current Pharmaceutical Design. July 1, 2011;17(21):2190-2195. doi:
10.2174/138161211796957490.
This investigation is complete; however additional results are pending publication.