Table of Contents
Introduction .................................................................................................................................. 24
Executive Summary ...................................................................................................................... 29
Biology and Biotechnology .......................................................................................................... 33
Animal Biology - Invertebrates
Drosophila Motility, Behaviour and Ageing (Ageing) .......................................................................... 34
Study of the Resistance of a Modeled Closed Ecosystem and Chains of its Components in
Microgravity (Akvarium) ..................................................................................................................... 36
Caenorhabditis elegans RNAi Space Experiment (CERISE) .................................................................. 39
Commercial Generic Bioprocessing Apparatus (CGBA), Three Investigations .................................... 41
Crickets in Space-2 (CRISP-2) .............................................................................................................. 44
Fungal Pathogenesis, Tumorigenesis, and Effects of Hose Immunity in Space (FIT) .......................... 46
International Caenorhabditis Elegans Experiment First Flight (ICE-First), Eight Investigations ......... 48
NanoRacks-University of Florida-1 (NanoRacks-UF-Squids-1) ............................................................ 55
Integrated Assessment of Long-term Cosmic Radiation Through Biological Responses of the
Silkworm, Bombyx mori, in Space (Rad Silk) ....................................................................................... 56
Study of the Growth Potential of Statoconia in the Organ of Balance of Gastropods in
Weightlessness (Statokonia) ............................................................................................................... 59
Cellular Modifications within the Vestibulo-ocular System during Adaptation to Microgravity in a
Developing Amphibian, Xenopus laevis (Xenopus) ............................................................................. 61
Avian Development Facility (ADF), Two Investigations ...................................................................... 63
Embryonic Development of Amphibians in Weightlessness (Aquarius) ............................................. 66
Commercial Biomedical Testing Module: Effects of Osteoprotegerin on Bone Maintenance in
microgravity (CBTM) ........................................................................................................................... 68
Commercial Biomedical Testing Module-2: (CBTM-2) ........................................................................ 71
Commercial Biomedical Testing Module-3: Assessment of sclerostin antibody as a novel bone
forming agent for prevention of spaceflight-induced skeletal frgility in mice (CBTM-3-Sclerostin
Antibody)............................................................................................................................................. 77
Commercial Biomedical Testing Module-3: STS-135 spaceflight’s affects on vascular atrophy in the
hind limbs of mice (CBTM-3-Vascular Atrophy) .................................................................................. 79
C. elegans to Assess Genomic Damage on Long-Duration Flights (Elerad) ......................................... 82
Mice Drawer System (MDS) ................................................................................................................ 84
Mouse Antigen Specific CD4+ T Cell Priming and Memory Response during Spaceflight (Mouse
Immunology) ....................................................................................................................................... 90
Effect of SpaceFlight on Innate Immunity to Respiratory Viral Infections (Mouse Immunology-2) ... 93