(Aryl-1/Aryl-2), Two Investigations Effect of Spaceflight Factors on the Expression of Producer Strains of Interleukin 1α, 1β, and Aryl
OF INTERLEUKIN 1 Α, 1 Β, AND ARYL (ARYL-1/ARYL-2), TWO INVESTIGATIONS
Research Area: Cellular Biology
Expedition(s): 16-24, 27-ongoing
Principal Investigator(s): ● Leonid N. Petrov, PhD, Biopreparat, Moscow, Russia
RESEARCH OBJECTIVES
The Effect of Spaceflight Factors on the Expression of Producer Strains of Interleukin 1α, 1 β, and
Aryl (Aryl) investigation develops a method of increasing the productivity of recombinant
producer strains of interleukins 1α, 1β, and Aryl (interleukin antagonist) medication by
incubating microorganism cultures in microgravity conditions and subsequently selecting the
best cultures. The essence of the research is to identify possible changes in physical, chemical,
morphological, and genetic properties of therapeutic and diagnostic bacteriophages exposed to
spaceflight factors that could
be used to obtain highly
effective medicines with
specific properties.
EARTH BENEFITS
The material obtained will be
used for selecting producer
strains with enhanced
properties (increased
productivity and segregation
stability) on Earth and
subsequently introducing
them into production. The
selected high-productivity
lines (clones) of producer
strains of interferon, interleukins, and Aryl will be used in the production of biological
medications at the State Scientific Research Institute of High Purity Biopharmaceuticals. The use
in production of these strain medications with enhanced properties could have a significant
economic impact.
SPACE BENEFITS
The essence of the research is the identification of possible changes in the physical, chemical,
morphological, and genetic properties of therapeutic and diagnostic bacteriophages exposed to
spaceflight factors that will be used to obtain highly effective medicines with specific
properties.
RESULTS
During the Aryl-1, the culture retained the capability to synthesize recombinant protein (Aryl).
Quantitatively speaking, the following differences were observed: when IPTG was used as the
Conducting the ARIL experiment on the ISS RS. Roscosmos image.