Pharmacology for Dentistry

122 Section 2/ Drugs Acting on CNS

effects include diarrhoea, abdominal
cramps, polyuria etc. The major side effect
is rise in serum transaminase and
hepatitis.

DONEPEZIL

It is another predominant centrally acting
ChE inhibitor and does not cause hepatotox-
icity. It is given in dose of 5-10 mg OD HS.

RIVASTIGMINE

It is given in a dose 6-12 mg/day for six

months and has been shown to improve

cognitive functions in patients of AD and it

has central ChE inhibitory action.

GALANTAMINE

It acts by dual mechanism i.e. inhibition

of central ChE and as an agonist on central

acetylcholine nicotinic receptors.

Other drugs which may have beneficial

property in the AD are antioxidants, beta

blockers and drugs from natural origin e.g.

Ginkgo biloba.