Sympathomimetics (Adrenergic Agents) 139in the treatment of peripheral vascular
diseases. But nylidrin is not used clinically.
Isoxsuprine has a potent inhibitory
effect on vascular and uterine smooth
muscle and has been used in the treatment
of dysmenorrhoea, threatened abortion,
premature labour and peripheral vascular
diseases. Adverse effects include nausea,
tachycardia, flushing and dizziness.
RITODRINE
It is β 2 selective agonist with uterine
relaxant property and preferred to suppress
premature labour and delay delivery of fetus.
But, use of ritodrine in suppressing labour has
been found to increase maternal morbidity and
neonate may develop hyperglycemia. So it
should not be used if mother has a history of
diabetes, heart disease or is on β-blocker or
steroid therapy.
Certain other drugs also having uterine
relaxant property are calcium channel
blockers, prostaglandin synthesis inhibitors,
progesterone, nitrites, anticholinergics,
ethyl alcohol etc.FENFLURAMINE
It is a sympathomimetic amine. the
mechanism of action is related to brain
levels (or turnover rates) of serotonin or
to increase glucose utilization. Its
antiappetite effect is suppressed by
serotonin blocking drugs. Its use in clinical
practice is recently banned in ‘India’
because of severe toxicity.