Parasympatholytics (Anticholinergic Agents) 165(COPD) by inhalation route. Titropium bro-
mide is congener of ipratropium bromide
producing long lasting bronchodilatation.
DICYCLOMINE
It has got antispasmodic with direct
smooth muscle relaxant action. It is used in
morning and motion sickness.
GLYCOPYRROLATE
Rapidly acting antimuscarinic lacking
central effects. Used for preanaesthetic
medication.
ISOPROPAMIDE
Indicated in hyperacidity, dyspepsia,
irritable bowel syndrome.
Propantheline, oxyphenonium,
panthienate are useful in peptic ulcer and
gastrointestinal hypermotility.
Pipenzolate and mephenzolate are
useful in dyspepsia and infantile colics.
MEBEVERINE
It shows effect on colonic muscle
activity. It is indicated in smooth muscle
spasm.PIRENZEPINE
Selective M 1 muscarinic receptor
blocker. It inhibits gastric secretion. Thus is
effective in peptic ulcer patients and
promotes ulcer healing. It does not produce
atropinic side effect (due to blockade of M 2
and M 3 receptors).
Only 20-30% oral bioavailability and is
excreted unchanged in urine.FLAVOXATE
It produces direct relaxant action on
smooth muscle with analgesic and
anaesthetic action and used in the treatment
of dysuria, nocturia and urinary urgency
and frequency associated with cystitis and
urethritis.