Pharmacology for Dentistry

Serotonin and its Antagonists 223

As 5-HT antagonist it is used in
controlling intestinal manifestations of
carcinoid and postgastrectomy dumping
syndrome. In addition, it has weak
anticholinergic and sedative properties
also.

Side effects include drowsiness, dry
mouth, weight gain and confusion.

KETANSERIN

Ketanserin is a highly selective 5-HT 2
antagonist and has no significant action on

5-HT 1 & 5-HT 3 receptors. It blocks 5-HT

induced vasoconstriction, platelet

aggregation and contraction of airway

smooth muscle.

In addition, it has adrenergic, H 1 and

dopaminergic blocking activity also.

Ketanserin is an effective antihyperten-

sive, but the mechanism of action is not

clear.

Side effects include dry mouth,

sedation, nausea, dizziness etc.