Tetracyclines, Chloramphenicol and Chemotherapy of UTI 315PHENAZOPYRIDINE
It is used for symptomatic relief of
urinary burning sensation and urgency due
to cystitis. It is a orange dye and excreted in
urine. It has no antibacterial property.
URINARY ALKALINIZERS AND ACIDIFIERSCertain antimicrobial agents used to treat
urinary tract infections act better in acidic
pH i.e. nitrofurantoin, tetracycline,
methenamine, cloxacillin. Certain other an-
timicrobial agents such as gentamicin,
cephalosporins, fluoroquinolones, cotri-
moxazole act better in alkaline medium. In
specific cases, where urine of desired reac-
tion (acidic or alkaline), some acidifying or
alkalinizing agents is sometimes used to
get a desired clinical result. Urinary pH
can be increased by carbonic anhydrase
inhibitors (e.g. acetazolamide) and
prolonged therapy requires bicarbonate
administration. In treatment of drug poi-
soning, the excretion of some drugs can
be hastened by acidification and alkalin-
ization of the urine. Ammonium chloride
is used to acidify urine and potassium ac-
etate/citrate is used to alkalinize urine.