Macrolide and Polypeptide Antibiotics 335BACITRACIN
This antibiotic is obtained from Bacillus
subtilis. It is effective against gram positive
(cocci and bacilli), Neisseria and H. influenzae.
It is used only topically as antibacterial pow-
der, skin and eye ointment and acts by inhib-
iting the cell wall synthesis. It is bactericidal.
TYROTHRICIN
It is obtained from Bacillus bravis and
effective against gram positive and some
gram negative organisms. It acts on bacte-
rial cell membrane causing leakage and
uncoupling of oxidative phosphorylation.
Used topically as skin cream and solution.