350 Section 9/ Chemotherapynancy. Apart from malaria, chloroquine in
also used in:- Rheumatoid arthritis.
- Giardiasis.
- Discoid lupus erythematosus.
- Infectious mononucleosis.
- Taeniasis.
- Lepra reactions.
- Hepatic amoebic abscess (used along
with metronidazole).
AMODIAQUINE
Another 4-aminoquinoline and pos-
sesses antimalarial activity similar to that
of chloroquine. It is useful in uncompli-
Table 9.8.1: Classification of antimalarial drugs.
I. 4-aminoquinoline derivative
Chloroquine (LARIAGO) Initially 600 mg, after 6 hr 300 mg followed by
300 mg daily for 3 days, 200-400 mg IM 6 hourly
Amodiaquine (CAMOQUIN) 25-35 mg/kg for 3 days
II. 8-aminoquinolines
Primaquine (MALIRID) 15 mg daily for 14 days
III. Quinoline-methanol derivatives
Mefloquine (MEFLOC) 15 mg/kg single dose (for treatment, maximum 1
g); 5 mg/kg, up to 250 mg per wk (for prophylaxis in
areas with multidrug resistance)
Bulaquine (AABLAQUIN) 125 mg (used with chloroquine 500 mg)
IV. Acridine derivative
Mepacrine (MALADIN) 900 mg 1st day, 600 mg on 2nd & 3rd day, 300 mg
on 4th, 5th and 6th day in divided doses; 600 mg/wk
for prophylaxis
V. Cinchona alkaloids
Quinine (as sulphate) 600 mg/day, oral TDS or 10 mg/kg with 5% glucose
IV infusion TDS (for cerebral malaria) for 7 days
VI. Biguanides
Proguanil (Chloroguanide; LAVERAN) 100 mg daily during exposure and continued for 6
weeks after exposure
VII.Diaminopyrimidine & Sulfonamides
Pyrimethamine (DARAPRIM) 25 mg (for prophylaxis)
Pyrimethamine 25 mg + sulfadoxine Once a week 3 tablets single dose
500 mg (MALARPRIM)
Pyrimethamine 25 mg + sulfamethopyrazine 3 tablets single dose
500 mg (METAKELFIN)
VIII.Artemisinin derivatives
Artesunate (FALCIGO) 100 mg BD on 1st day, followed by 50 mg BD for
next four days (for cerebral malaria, chloroquine-
resistant malaria & P. falciparum malaria).
Artether (EMAL) 150 mg daily for 3 days IM
Artemether (LARITHER) 160 mg BD on first day and 80 mg OD for next four
days orally; 80 mg BD IM on first day and 80 mg OD
IM for next four days IM