Pharmacology for Dentistry

38 Section 1/ General Principles of Pharmacology

1

2

3

4

5

6

24 6 8 10 12 14

MTC

MEC

Plasma concentration (μg/ml)

Time (hr.)

• First
  dose
  
  
  • Second
    dose
  
  
  
  

Fig. 1.4.5: Shows the administration of 2nd dose
between the 7-8 hours interval which maintains the
drug plasma levels above minimum effective
concentration.

1

2

3

4

5

6

24 6^810 12 14

MTC

MEC

Plasma concentration (μg/ml)

Time (hr.)

• First
  dose
  
  
  • IInd
    dose
  
  
  
  

Fig. 1.4.6: Shows the administration of 2nd dose after

7-8 hours interval which does not maintain the drug

plasma concentration at MEC level.

24 6 8 10 12 14

1

2

3

4

5

6

—Ist

dose

— 2nd

dose

MTC

MEC

Plasma concentration (μg/ml)

Time (hr.)

Fig. 1.4.7: Shows the administration of 2nd dose

before 7-8 hours interval which crosses the MTC which

may produce toxic effects of drugs.