Pharmacology for Dentistry

68 Section 2/ Drugs Acting on CNS

ANTICHOLINERGICS

Atropine (0.06 mg IM, IV) or scopola-
mine is generally given in combination with
morphine to block the vagal action so as to
reduce the salivary and bronchial secretions.

They also prevent vagal bradycardia and
hypotension during operation. Hyoscine
produces amnesia and antiemetic effect also.

NEUROLEPTICS

Chlorpromazine (25 mg), triflupromazine

(10 mg) or haloperidol (2-4 mg) IM are used

as preanaesthetic medication. They reduce

anxiety, emesis and help in smooth induction.

However, these compounds potentiate

respiratory depression.

ANTIEMETICS

Droperidol and hydroxyzine (25-50 mg

IM) is sometime used for their antiemetic

activity. Hydroxyzine has antianxiety,

antihistaminic and anticholinergic proper-

ties also.