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may either proceed sequentially, starting from one end of the protein, or may involve a ‘hairpin’ conformation of the protein en ...

16 Principles of clinical biochemistry J. FYFFE AND K. WILSON 16.1 Principles of clinical biochemical analysis 16.2 Clinical mea ...

The concentration, amount or activity of a given cell component that can be detected in these fluids of a healthy individual at ...

more severe cases, actually dying (necrosis) and releasing their contents into the surrounding extracellular fluid. In the vast ...

carbamezepine (both of which are used in the treatment of epilepsy) that have a low therapeutic index (ratio of the dose require ...

The correct interpretation of all biochemical test data is heavily dependent the use of the correct reference range against whic ...

To achieve an effective service, a clinical biochemistry laboratory has three main functions: to advisethe requesting GP or hos ...

The advice given to the clinician is generally supported by a User Handbook, prepared by senior laboratory personnel, that inclu ...

urine, cerebrospinal fluid (the fluid surrounding the spinal cord and brain), faeces, sweat, saliva and amniotic fluid. It is es ...

combined into a single unit, is used to measure electrolyte concentrations of Naþ,Kþ and Clsimultaneously with an analytical ti ...

tests are then automatically prioritorised into the most efficient order and the analyser programmed to take the appropriate vol ...

Solution inlet Reference inlet Waste (a) Counter electrode Glucose Lactate pCO 2 pH K+ Ca++ Na+ Reference electrode pO 2 Haemato ...

peroxide which then diffuses through a controlling layer (Fig. 16.2b) and is oxidised by the platinum electrode to release elect ...

acyl-CoA dehydrogenase deficiency (MCADD) andorganic acidaemiassuch as propionic acidaemia caused by a deficiency of the enzyme ...

and against nationally agreed standards. In the context of analytical procedures, the audit evaluates the laboratory performance ...

Closely allied to the process of clinical audit is that ofaccreditation. However, whereas clinical audit is carried out primaril ...

that the laboratory is in compliance with the standards and hence provides quality healthcare. The accreditation normally lasts ...

Serum-specific enzymes: The normal physiological function of these enzymes is based in serum. Examples include theenzymes assoc ...

treatment of the patient is a valuable indicator of the patient’s recovery from the condition. The practical implication of thes ...

Aspartate aminotransferase(AST): This is one of a number of transaminases involved in intermediary metabolism. It is found in m ...