Medicinal Chemistry

rheumatoid arthritis. Some of these compounds are powerful enough to be effective against the major pain caused by malignancies. ...

8.5.3 Anti-Leukotrienes as Anti-Inflammatory Agents for Asthma Like the other eicosanoids, the leukotrienes are also involved in ...

8.6 Carbohydrates as Drugs and Drug Design Targets Carbohydrates are underexploited as receptors against which to target drugs a ...

α-D-glucuronic acid,α-L-iduronic acid,α-D-glucosamine, and N-acetyl-α-D-glucosamine. These monosaccharide units are partially su ...

This chapter focuses primarily on endogenous molecules as nonmessenger targets for drug design. There are many such molecules. A ...

women to make their ocular pupils look darker and thus supposedly more attractive), and cocaine (8.88, from Erythroxylon coca). ...

barbiturates, carbamazepine, chloramphenicol, diazepam, diclofenac, diphenhydramine, enalapril, erythromycin, flucloxacillin, fu ...

of action is unknown, they may function by inhibition of the enzyme phosphofructokinase within the parasite. 8.8.1.2 Bismuth Bis ...

patients experiencing serious side effects which include diarrhea, oral ulcerations, kidney damage with protein in the urine (pr ...

8.8.1.7 Zinc Zinc is used for a variety of indications. Zinc acetate (8.102) or, rarely, zinc sulfate (8.103) have been used ora ...

(compact) bone and trabecular (cancellous) bone. More than 80% of the skeleton is composed of cortical bone, a dense tissue that ...

of future osteoporosis. Approximately 1200–1500 mg of elemental calcium per day is suggested for teenagers. Calcium supplementat ...

to be balanced against the risk of breast cancer and other shortcomings associated with chronic estrogen replacement. Selected R ...

E. Erdman, K. Werdan, L. Brown (1985). Multiplicity of cardiac glycoside receptors in the heart. Trends Pharmacol. Sci. 6: 293–2 ...

R. A. Maxwell, H. L. White (1978). Tricyclic and monoamine oxidase inhitor antidepressants: structure–activity relations. In: L. ...

A. Y. Kornilova, M. S. Wolfe (2001). Secretase inhibitors for Alzheimer’s disease. Annu. Rep. Med. Chem. 38: 41. J. P. Taylor, J ...

J. A. Salmon (1997). Inhibition of prostaglandin, thromboxane and leukotriene biosynthesis. Adv. Drug Res. 15: 111–167. B. Samue ...

9 Nonmessenger Targets for Drug Action III Exogenous pathogens and toxins 543 9.1 EXOGENOUS PATHOGENS AS TARGETS FOR DRUG DESIGN ...

to the tissues of the heart, causing oxygen deprivation and hypoxicdamage to the heart muscles. Rational drug design for disease ...

Chemistry of the American Chemical Society (which document new drugs introduced on a yearly basis) verifies this and reveals tha ...