D. M. Richards, R. N. Brogden, R. C. Heel, T. M. Speight, G. S. Avery (1984). Astemizole:
a review of its pharmacological properties and therapeutic efficacy. Drugs 28: 38–61.
J.-C. Schwartz, J.-M. Arrang, M. Garbarg (1986a). Three classes of histamine receptors in the
brain.Trends Pharmacol. Sci. 7: 24–28.
J.-C. Schwartz, J.-M. Arrang, M. Garbarg, M. Komer (1986b). Properties and roles of the three
subclasses of histamine receptors in the brain. J. Exp. Biol. 124: 203–224.
F. E. Simons, K. J. Simons (1999). Clinical pharmacology of new histamine H1 receptor antagonists.
Clin. Pharmacokinet. 36: 329.
K. Sugano, Y. Fukushima (2000). Molecular biology of histamine H2 receptor. Therap. Res. 21 :
S245–S250.
H. Timmerman (1999). Why are non-sedating antihistamines non-sedating? Clin. Exp. Allergy
29 : 13–18.
A. Togias (2003). H1-receptors: localization and role in airway physiology and in immune func-
tions. J. All. Clin. Immunol. 112: S60–S68.
GABA and GABA Receptors
P. R. Andrews, G. A. R. Johnston (1979). GABA agonists and antagonists. Biochem. Pharmacol.
28 : 2697–2702.
E. Ben-Menachem (1995). Vigabatrin. Epilepsia 36(Suppl. 2): S95.
N. Bouche, B. Lacombe, H. Fromm (2003). GABA signaling: a conserved and ubiquitous mech-
anism.Trends Cell Biol. 13 : 607–610.
A. C. Bowling, R. J. Delorenzo (1982). Micromolar activity BZD receptors: identification and
characterization in the CNS. Science 216: 1247–1249.
M. J. Brodie, R. J. Porter (1990). New and potential anticonvulsants. Lancet 336: 425.
H. M. Bryson, B. R. Fulton, D. Faulds (1995). Propofol: an update of its use in anaesthesia and
conscious sedation. Drugs 50: 513.
M. Chebib, G. A. R. Johnston (1999). The “ABC” of GABA receptors: a brief review. Clin. Exp.
Pharmacol. Physiol. 26: 937–940.
E. Costa (1982). Do benzodiazepines act through a GABAergic mechanism? In: A. M. Creighton,
and S. Turner (Eds.). Chemical RegulationofBiological Mechanisms. London: Royal
Society of Chemistry.
E. Costa, G. di Chiara, G. L. Gessa (Eds.) (1980). GABA and Benzodiazepine Receptors.
Advances in Biochemical Pharmacology, vol. 26. New York: Raven Press.
E. Costa, A. Guidotti (1996). Benzodiazpines on trial: a research strategy for their rehabilitation.
Trends Pharmacol. Sci. 17: 192.
F. V. DeFeudis (1982). γ-Aminobutyric acid and analgesia. Trends Pharmacol. Sci. 3: 444–446.
R. C. Effland, M. F. Forsch (1992). Anti-anxiety agents, anticonvulsants and sedative-hypnotics.
Ann. Rep. Med. Client. 17: 11–19.
F. J. Ehlert (1986). “Inverse agonists,” cooperativity and drug action at benzodiazepine receptors.
Trends Pharmacol. Sci. 7: 28–32.
S. L. Erdö (1985). Peripheral GABAergic mechanisms. Trends Pharmacol. Sci. 6: 205–208.
U. Grunert (1999). Distribution of GABAA and glycine receptors in the mammalian retina.
Clin. Exp. Pharmacol. Physiol. 26: 941–944.
W. Haefely, E. Kyburz, M. Gerecke, H. Möhler (1985). Recent advances in the molecular
pharmacology of benzodiazepine receptors and the structure–activity relationship of their
agonists and antagonists. In: B. Testa (Ed.). Advanced Drug Research, vol. 14. New York:
Academic Press, pp. 165–322.
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