Medicinal Chemistry

(Jacob Rumans) #1

This observation opens a window of opportunity, enabling a partially selective targeting
of tumor cells in preference to host cells. By designing agents which attack nucleic
acids at particular times during the cell cycle, it is possible to devise molecules with
improved specificity for tumor cells.


Selected References


Membrane Ion Channel Targets


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D. Chapman (Ed.) (1984). Biomembrane Structure and Function, Topics in Molecular and
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M. J. Coghlan, W. A. Carroll, M. Gopalakrishnan (2001). Recent developments in the biology and
medicinal chemistry of potassium channel modulators: update from a decade of progress.
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M. Concepcion, B. G. Covino (1984). Rational use of local anesthetics. Drugs 27: 256–270.
N. D. P. Cosford, P. T. Meinke, K. A. Stauderman, S. D. Hess (2002). Recent advances in the
modulation of voltage-gated ion channels for the treatment of epilepsy. Current Drug
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C. R. Craig, R. E. Stitzel (Eds.) (1986). Modern Pharmacology, 2nd ed. Boston: Little, Brown.
C. de Dove (1984). A Guided Tour of the Living Cell. San Francisco: Scientific American Books.
D. A. Doyle, J. M. Cabral, R. A. Pfuetzner, A. Kuo, J. M. Gulbis, S. L. Cohen, B. T. Chait,
R. MacKinnon (1998). The structure of the potassium channel: molecular basis of K+conduc-
tionand selectivity. Science 280: 69–77.
H. Glossman, D. R. Ferry, A. Goll, J. Striessnig, G. Zernig (1985). Calcium channels and calcium
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V. K. Gribkoff, J. E. Starrett, Jr. (2002). Advances in technologies for the discovery and charac-
terization of ion channel modulators: Focus on potassium channels. Annu. Rep. Med. Chem.
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A. K. M. Hammarstroem, P. W. Gage (2002). Hypoxia and persistent sodium current. Eur.
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B. Hille (1984). Ionic Channels of Excitable Membranes. Sunderland, MA: Simmer.
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Y. Jiang, A. Lee, J. Chen, M. Cadene, B. T. Chait, R. MacKinnon (2002). Crystal structure and
mechanism of a calcium-gated potassium channel. Nature 417: 515–522.
T. H. Large, M. W. Smith (2001). Screening strategies for ion channel targets. In:Drugs and the
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R. Mannhold (1984). Calmodulin—structure, function and drug action. Drugs Future 9: 677–691.


ENDOGENOUS CELLULAR STRUCTURES 463
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