Medicinal Chemistry

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Table 8.2 Caspases Relevant to Drug Design

Caspace Alternate nonmenclature Function Substrates

Caspase-1 ICE Processing of interleukins Interleukin-18
(inflammation) Lamins
pre-Interleukin-1β
Caspase-2 Ich-1 Apoptosis Golgin-160
Caspase-3 CPP32 Apoptosis β-Catenin
Calpastatin
Caspase-6
Caspase-7
Caspase-9
DNA–PK
FAK
Fodrin
Gas2
Gelsolin
HnRNP proteins
ICAD
Lamins
MDM2
PARP
Presenilin2
Topoisomerase I
Caspase-4 Ich-2, ICE II Caspase-1
Caspase-5 ICE III, TY Inflammation/Apoptosis
Caspase-6 Mch2 Apoptosis Caspase-3
FAK
Keratin-18
NuMA
PARP
Caspase-7 Mch3, ICE-LAP3, CMH-1 Apoptosis Calpastatin
EMAP II
FAK
PARP
SREB1
Caspase-8 FLICE, MACH, Mch5 Apoptosis Caspase-3
Caspase-4
Caspase-6
Caspase-7
Caspase-9
Caspase-10
Caspase-13
PARP
(Continued)