Medicinal Chemistry

Figure 8.9

Prostaglandins and leukotrienes are potent eicosanoid lipid mediators,

derived from phospholipase-released arachidonic acids, that are

involved in numerous homeostatic biological functions and inflammation.

They are generated by cyclooxygenase isozymes and 5-lip

oxygenase, respectively,

and their biosynthesis and pharmacological actions are inhibited by clinically rele

vant nonsteroidal anti-inflammatory drugs.

521