Medicinal Chemistry

563

Table 9.2

Sensitivities of Some Organisms to Commonly Used Antibiotics

Drug

1234567891

01112131415161718

192021

Ampicillin/Amoxicillin

************

**

**

**

Cefoxitin

*

Ceftazidime

***

Cefuroxime/cefotaxime

*

*

*

*

**

*

*

*

cefamandole

Chloramphenicol

*

*

*

*

*

Co-trimoxazole

*

*

*

*

**

**

**

*

*

Erythormycin

****

*

*

**

***

Gentamicin

*

*

*****

Flucloxacillin

**

**

Metronidazole

**

Penicillin G/Penicillin V

**

**

**

**

**

**

**

*

Piperacillin

*

**

Quinolones

****

**

**

Tetracyclines

*

*

*

*

**

*

*

**

**

** Drug of first choice.* Drug of second choice. 1 Staphylococcus aures

(penicillin-sensitive);

2 Staphyloccocus aureus

(penicillin-resistant);

3 Streptococcus pyogenes

(^4) ;
Streptococcus pneumoniae
(^5) ;
Enterococcus faecalis
;
6 Viridans’ streptococci
(^7) ;
Neisseria meningitidis
(^8) ;
Neisseria gonorrhoeae
(^9) ;
Haemophilus influenzae
(^10) ;
Escherichia coli
(^11) ;
Klebsiella
;
12 Proteus mirabilis
(^13) ;
Pseudomonas
aeruginosa
(^14) ;
Brucella
(^15) ;
Legionella pneumophila
(^16) ;
Salmonella typhi
(^17) ;
Bacteroides spp

. and other anaerobes;

18 Mycoplasma pneumoniae

(^19) ;
Chlamydiae
(^20) ;
Listeria mono-
cytogenes
(^21) ;
Rickettsiae.
(Adapted from D. G. Grahame-Smith, J. K. Aronson (2002).
Clinical Pharmacology and Drug Therapy
, 3rd Edn. New York: Oxford University Press. With permission.)