Mebendazole (9.120), a synthetic benzimidazole, is a broad-spectrum oral antihelminthic
used for ascariasis, pinworm infestation, and hookworm infestation. It is thought to
work by blocking microtubule synthesis in the nematode, subsequently impairing
glucose uptake.
Metrifonate (9.121), an organophosphate compound, is a low-cost antihelminthic
used to treat Schistosoma hematobium infections. The drug appears to alter
cholinesterase activity in the nematode, temporarily paralysing the adult worm and
causing the worm to die. Because of its activity against the cholinesterase enzyme, this
drug has also been evaluated as a treatment for Alzheimer’s disease.
EXOGENOUS PATHOGENS AND TOXINS 589