Medicinal Chemistry

Index

629

Aβpeptide, 513, 515, 516
ab initio calculations, 46
abacavir, 555
abortion, threatened spontaneous, 326
absolute configuration, 476
absorption, drug, 13
acarbose, 367, 369
accessory binding sites, receptor, 87
ACE inhibitors, 373–376, 380, 535
acedapsone, 579
acetazolamide, 495
acetohexamide, 367
acetylcholine, 33, 204–209, 486–491
metabolism, 206
receptors, 207
acetylcholinesterase, 484, 486–491
acetylcholinesterase inhibitors, 487–488
acetylsalicylic acid, 473, 484, 525
AChE, 486–491
acini, 360
acipimox, 320
acquired immune deficiency syndrome,
119, 554–556, 582
ACTH, 311, 315, 332, 346, 347–348
actin, 426
actinomycin D, 444, 445
action potential, 194–196
acute intermittent porphyria, 531
acyclovir, 18, 471, 552–553
adaptive immunity, 391
Addison’s disease, 336, 348
adenine nucleotide, 470
adenosine, 18
adenosine neuromodulators, 297, 298
adenosine triphosphatase, 492–494

adenylate cyclase, 484, 524

adenylate cyclase receptor system, 93–95

adhesion molecules, 392

ADME, 102, 146

adrenal cortex, 332

adrenal glands, 311

adrenal medulla, 332

adrenal steroids, 331–337

adrenal suppression, 336

adrenergic receptor, 218, 222–225

adrenocorticoids, 311, 312, 331–337, 474

adrenocorticotropic hormone, 311, 315, 332,

346, 347–348

adriamycin, 157

affinity, drug-receptor, 76

AFP, 516

agonist, 75, 76

partial, 76

AIP, 531

alanine scan, 114

β-alanine, 296, 297

albendazole, 588

albuterol, 232

alcohol metabolism, 150

aldehyde metabolism, 151

aldol reaction, 166, 172

aldose reductase inhibitors, 370

aldosterone, 337

alendronate, 536

aliphatic electrophilic substitution, 128

aliphatic nucleophilic substitution, 128

alkaloids, 480

alkane metabolism, 149

alkene epoxidation, 147

alkene metabolism, 150