naphazoline, 229
naproxen, 525
natriptam, 260
natriuresis, 376
natriuretic factor, 311, 376–378
NE, 498
necrosis, 500, 501
nelfinavir, 556
neomycin, 574
neoplasm, 459
neospinothalamic path, 353
neostigmine, 488
NEP, 377
nerve conduction, 195–197
nerve gas agents, acetylcholinesterase
inhibitors and, 491
nerve growth factor, 401, 432
nervous system, 310
netilmycin, 575
neuroendrocrinology, 339
neurogenic bladder, 212
neurohormones, 311
neurokinins, 291
neuroleptics, 243, 244
neuromodulator, definition, 197
neuromuscular blocking agent, 215
neuromuscular endplate, 194
neuron, 194–196
neuropeptide Y, 290
neuropeptides, 289, 311, 338–346
neuroprotectants, 287
neurotransmitter, definition, 197
neurotransmitters, 310, 311
neurotrophins, 401
neutral endopeptidase, 377
neutrophil, 390
nevirapine, 555
new chemical entity, 5, 9
Newman projection, 33
Newton, Isaac, 110, 119
Newton-Raphson method, 49
niacin, 505
nicardipine, 428
niclosamide, 590
nicorandil, 424
nicotinamide, 505
nicotinamide adenine dinucleotide, 480
nicotine, 206, 480
nicotinic acid, 320, 480, 505
nicotinic receptors, 205
NIDDM, 369–370
nifedipine, 380, 427
nimodipine, 427
nipecotic acid, 272
nisoldipine, 428
nitration, in drug synthesis, 181
nitrendipine, 428
nitric oxide, 291, 292
nitric oxide synthase, 292
nitro group metabolism, 148
nitrogen mustards, 446
nitroglycerin, 296
nitroprusside, 18, 296
nitrosoureas, 448
NMDA, 284–286, 432
nocardicin, 569
nociceptive stimuli, 353
node of Ranvier, 194
NOESY experiments, 60
nomifensine, 242
noncompetitive inhibitors, 484
nonself targets, 387, 461, 545
nonsteroidal anti-inflammatory drugs, 524–525
norepinephrine, 14, 218–224
norethindrone, 326, 327
norfloxacin, 580
norgestimate, 327
norgestrel, 326, 327
N-normorphine, 356
nortriptyline, 237
Norwalk virus, 549
NOS enzyme, 292
nosocomial infection, 592
NPH, 366, 367
NPY, 290
NSAIDs, 524–525
nucelic acids as drugs and targets, 517–519
nuclear magnetic resonance, 58–59
nucleic acids, 469–471
nucleophilic substitutions, 168, 169, 174, 181
nucleosides, 469
nucleotide reverse transcriptase inhibitors, 554
nucleotides, 469
nucleotidomimetic chemistry, 115, 518
nyctalopia, 509
nystagmus, 201
nystatin, 583
obesity, 290
occipital lobe, 201
occupation theory, receptor, 78
octanol-water partition coefficient, 10, 27–30, 143
octopamine, 227
octreotide, 345
oils, 471–472
olanzapine, 245
oleandomycin, 576
oligodendrocytes, 195
oligonucleotide libraries, 123
oligopeptide, 338
642 INDEX