Medicinal Chemistry

oligopeptide libraries, 123
oligosaccharide, 475
omeprazole, 268, 494
oncogenes, 95
Ondetti, 373
one target-multiple disease approach, 378
opiate antagonists, 359
opiate hormones
biochemical effects, 354
peptide, 350–359
pharmacological effects, 354
physiological effect, 353–354
receptors, 352–353
opium alkaloids, 354–356
opsonin, 391
optic neuritis, 397
optical isomers, 37
oral administration, 11
oseltamivir, 557
osmotic minipump, 159
osteoblasts, 536
osteoclasts, 536
osteoporosis, 324, 536
ouabain, 17, 436
Overton hypothesis, 28
ovulation inhibitors, 327–328
oxacillin, 566
oxamniquine, 590
oxandrolone, 329
oxazepam, 102, 275
oxidation, drug metabolism, 146
oxidoreductases, 468
oxilorphan, 359
oxotremorine, 210
oxprenolol, 235
oxybutynin, 213
oxymorphone, 356
oxymurcuration, 174
oxyphencyclimine, 214
oxytetracycline, 573
oxytocic activity of prostaglandins, 523
oxytocin, 346, 348–349
ozonolysis, 177

paclitaxel, 455
Paget’s disease, 536
paleospinothalamic path, 353
pamidronate, 536
pancreas, 311
pancreatic peptide hormones, 364–371
pancuronium, 215
pantothenic acid, 506
papaverine, 354, 531
parafollicular cells, 360
paragyline, 499

parahormone, 311, 360, 363–364, 510

paranoid psychosis, 243

paraquat, 594

parasites, 584

parasympathetic nervous system, 203

parasympatholytics, 212

parathyrin, 311, 360, 363–364

parathyroid, 311, 510

parathyroid hormone, 311, 360, 363–364

parietal lobe, 201

Parkinson’s disease, 112, 247–248

paromomycin, 574

paroxetine, 253

Pasteur, L., 36

pathogenesis, definition, 187

pathogens, 544

pathological process approach, 186

pattern recognition, 144

pellagra, 505

penciclovir, 553

penicillamine, 595

penicillin, 18, 71, 485, 564–567

penicillin G, 564

pentazocine, 138, 357, 359

pentobarbital, 278

pepstatin, 372

peptide backbone, 338

peptide neurotransmitters, 288–291

peptides, 466–469

definition, 466

peptidic hormones, 310, 338–382

peptidic ulcers, 267, 268

peptidomimetic chemistry, 113

peracid oxidation, 179

peramivir, 557

perchlorate, 362

pergolide, 248

perindopril, 375

peripheral oedema, 350

permanganate oxidation, 178

pernicious anemia, 507

pertechnetate, 362

PG cyclooxygenase, 520

PGA, 520

PGB, 520

PGC, 520

PGD 2 , 520, 522

PGE 1 , 473, 522, 525

PGE 2 , 520, 522, 523, 524

PGF 2 , 520, 522, 523, 524

PGG, 520

PGG 2 , 525

PGH 2 , 520, 523, 525

PGI 2 , 520, 522, 523, 524

PGJ 2 , 522

INDEX 643