pH, tissue fluids, 13
phagocytosis, 390
pharmaceutical phase, 10–15
pharmacodynamic phase, 10, 17–19, 134–139
pharmacogenomics, 127
pharmacokinetic phase, 10, 15–17
pharmacophore, 8, 19–20, 106
identification, 145
pharmacophoric pattern, 18
phase I metabolism, 146
phase II metabolism, 146
phenacetin, 157
N-phenethyl-levorphanol, 357
N-phenethyl-normorphine, 356
phenformin, 367, 368
phenobarbital, 14, 18, 279, 422
phenol, 571
phenol metabolism, 150
phenothiazine, 244
phenoxybenzamine, 230
phentermine, 255
phentolamine, 229
phenylalkylamines, 427
phenylbutazone, 525
phenylephrine, 229
phenylethylamine, 497
phenytoin, 14, 15, 16, 27, 31, 102,
122, 161, 279, 422, 431
pheochromocytoma, 230
pheromones, 474
phospharamide, 448
phosphatidylcholine, 409
phosphoglycerides, 472, 473
phospholipase A, 520
phospholipids, 472
phosphorothioate oligodeoxynucleotides, 519
photodynamic therapy, 458
physicochemical descriptors, 53, 143
physiological systems approach, 186
physostigmine, 488, 490
pia mater, 201
pifluthixol, 245
piloerection, 353
pimozide, 244, 245
pinacidil, 423
pinacol rearrangement, 177
Pincus, 326
pindolol, 236
pineal gland, 200
α-pinene, 474
pinworm, 585
pioglitazone, 367, 369
piperacillin, 567
piperidine derivatives as morphine
analogues, 357–358
piperidine metabolism, 152
piperoxan, 230
pirenzepine, 268
piroxicam, 525
pitressin, 350
pituitary gland, 200, 310, 311
pivampicillin, 156
plants as drug sources, 117
plaque, 515
plasmodium falciparum, 546–586
platinum, 454, 534
PM3 calculations, 46
PMS, 326
PN 202–791, 429
pneumonia, 591
podophyllotoxins, 453
polarizability, 41
polyglutamine-containing protein, 514
polypharmacy, 101, 102
polysaccharide, 475
polytherapy, 380
polythiazide, 496
pons, 198
porfimer, 459
porphin, 479
porphyria, 531–532
positive inotropic effect, 492
posterior pituitary peptide hormones, 348–350
potassium antimony tartrate, 533
potassium channel, 423–424
potency, 77
pralidoxime, 491
pramipexole, 248
pravastatin, 318
praziquantel, 590
prazosin, 230, 381
pre-eclampsia, 294
pre-proangiotensin, 372
prednisone, 136, 334, 394
premenstrual syndrome, 326
prenalterol, 232
preproANP, 376
prilocaine, 417
primary structure, peptide, 466
primidone, 279
prion-induced dementia, 514–515
prions, 514, 546–547
privileged structure, 238, 274
procainamide, 18, 421
procaine, 14, 155, 416, 417, 531
prodrugs, 154–155
proflavine, 444
progabide, 273
progesterone, 158, 325
progestins, 311, 325–328644 INDEX